The Komor Lab

Vasquez, C. A.; Evanoff, M.; Ranzau, B. L.; Dieters, E.; Komor, A. C.* “Curing ‘GFP-itis’ in Bacteria with Base Editors: Development of a Genome Editing Science Program Implements with High School Biology Students,” CRISPR J. 2023, 6, 186-195. PubMed

Ranzau, B. L.; Rallapalli, K. L.; Evanoff, M.; Paesani, F.; Komor, A. C.* “The wild-type tRNA adenosine deaminase enzyme TadA is capable of sequence-specific DNA base editing,” ChemBioChem. 2023, e202200788. Designated a “Very Important Paper”, or top 10% of ChemBioChem articles. Cover Article PubMed

Porto, E. M.; Komor, A. C.* “In the business of base editors: Evolution from bench to bedside,” PLoS Biol. 2023, 21, e3002071. PubMed

Rallapalli, K. L.; Komor, A. C.* “The Design and Application of DNA Editing Enzymes as Base Editors,” Annu. Rev. Biochem. 2023, 92. PubMed

Burnett, C.A.; Wong, A.T.; Vasquez, C.A.;McHugh C.A.; Yeo, G.W.; Komor, A. C. “Examination of the Cell Cycle Dependence of Cytosine and Adenine Base Editors,” Frontiers in Genome Editing. 2022, 39 PubMed

Bodai, Z.; Bishop, A. L.; Gantz, V. M.; Komor, A. C. “Targeting Double Strand Break Indel Byproducts with Secondary Guide RNAs Improves Cas9 HDR-Mediated Genome Editing Efficiencies,” Nat. Commun. 2022, 13, 2351. PubMed

Bishop, A. L.; Lopez del Amo, V.; Okamoto, E.; Bodai, Z.; Komor, A. C.; Gantz, V. M. “Double-Tap Gene Drive: Iterative Genome Targeting Helps Overcome Resistance Alleles,” Nat. Commun. 2022, 13, 2595. PubMed

McDaniel, S.; Komor, A. C.*; Goren, A* “The use of base editing technology to characterize single nucleotide variants,” Computational and Structural Biotechnology Journal. 2022, 20. PubMed

Rallapalli, K. L.; Ranzau, B. L.; Ganapathy, K. R.; Paesani, F.*; Komor, A. C.* “Combined Theoretical, Bioinformatic, and Biochemical Analyses of RNA Editing by Adenine Base Editors,” CRISPR J. 2022, 5, 294-310. PubMed

Weng, N.; Miller, M.; Pham, A. K.; Komor, A. C.; Broide, D. H. “Single base editing of rs12603332 on Chromosome 17q21 with a Cytosine Base Editor regulates ORMDL3 and ATF6a expression,” Allergy 2022, 77, 1139-1149. PubMed

Rees H.A.; Minella, A.C.; Burnett, C.A.; Komor, A. C.*; Gaudelli, N. M.* “CRISPR-derived Genome Editing Therapies: From Bench to Bedside,” Mol. Ther. 2021, 29, 1-15. PubMed

Gu, S; Bodai, Z; Cowan, Q. T.; Komor, A. C. “Base Editors: Expanding the Types of DNA Damage Products Harnessed for Genome Editing,” Gene and Genome Editing 2021, 1, 100005. PubMed

Gaudelli, N. M.*; Komor, A. C.* “Celebrating Rosalind Franklin’s Centennial with a Nobel Win for Doudna and Charpentier,” Mol. Ther. 2020, 28, 2519-2520. PubMed

Vasquez, C. A.; Cowan, Q. T.; Komor, A. C. “Base Editing in Human Cells to Produce Single Nucleotide Variant Clonal Cell Lines,” Curr. Protoc. Mol. Biol. 2020, 133, e129. PubMed

Porto, E. M.; Komor, A. C.; Slaymaker, I. M.; Yeo, G. W. “Base Editing: Advances and Therapeutic Opportunities,” Nat. Rev. Drug Disc. 2020, 19, 839. PubMed

Rallapalli, K. L.; Komor, A. C.; Paesani. F. “Computer Simulations Explain Mutation-induced Effects on DNA Editing by Adenine Base Editors,” Sci. Adv. 2020, 6, eaaz2309. PubMed

Quinn, R. A. et al. “Global Effects of the Microbiome Include New Bile-acid Conjugations,” Nature, 2020, 579, 123-129. PubMed

Fox, K.; Rallapalli, K. L.; Komor, A. C. “Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools,” Genes, 2020, 11, 88. PubMed

Evanoff, M. E. and Komor, A. C. “Base Editors: Modular Tools for the Introduction of Point Mutations in Living Cells,” Emerging Topics in Life Sciences, 2019, ETLS20190088. PubMed

Davies, K.; Komor, A. C.; Gaudelli, N.M. “The Beginning of Base Editing: An Interview with Alexis C. Komor and Nicole M. Gaudelli,” The CRISPR Journal, 2019, 2, 81-90. PubMed

Ranzau, B. L. and Komor, A. C. “Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells,” Biochemistry, 2019, 58, 330-335. PubMed

Komor, A. C.; Badran, A. H.; Liu, D. R. “Editing the Genome Without Double-Stranded DNA Breaks,” ACS Chem. Biol. 2018, 13, 383-388. PubMed

Gaudelli, N. M.; Komor, A. C.; Rees, H. A.; Packer, M. S.; Badran, A. H.; Bryson, D. I.; Liu, D. R. “Programmable Base Editing of A•T to G•C in Genomic DNA without DNA Cleavage,” Nature 2017, 551, 464-471. PubMed

Komor, A. C.; Zhao, K. T.; Packer, M. S.; Gaudelli, N. M.; Waterbury, A. L.; Koblan, L. W.; Badran, A. H.; Liu, D. R. “Improved Base Excision Repair Inhibition and Bacteriophage Mu Gam Protein Yields C:G-to-T:A Base Editors with Higher Efficiency and Product Purity,” Sci. Adv. 2017, 3, eaao4774. PubMed

Rees, H. A.; Komor, A. C.; Yeh, W. H.; Caetano-Lopes, J.; Warman, M.; Edge, A. S. B.; Liu, D. R. “Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery,” Nat. Commun. 2017, 8, 15790. PubMed

Kim, Y. B.; Komor, A. C.; Levy, J. M.; Packer, M. S.; Zhao, K. T.; Liu, D. R. “Expanding the targeting scope of base editing with engineered Cas9-cytidine deaminase fusions,” Nat. Biotechnol. 2017, 35, 371-376. PubMed

Komor, A. C.; Badran, A. H.; Liu, D. R. “CRISPR-based technologies for the manipulation of eukaryotic genomes,” Cell 2017, 168, 20-36. PubMed

Komor, A. C.; Kim, Y. B.; Packer, M. S.; Liu, D. R. “Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage,” Nature 2016, 533, 420-424. PubMed

Komor, A. C.; Barton, J. K. “An Unusual Ligand Coordination Gives Rise to a New Family of Rhodium Metalloinsertors with Improved Selectivity and Potency,” J. Am. Chem. Soc. 2014, 136, 14160-14172. PubMed

Weidmann, A. G.; Komor, A. C.; Barton, J. K. “Targeted Therapy with Metal Complexes,” Comment. Inorg. Chem. 2014, 34, 1-10. PubMed

Bailis, J. M.; Gordon, M. L.; Gurgel, J. L.; Komor, A. C.; Barton, J. K.; Kirsch, I. R. “An Inducible, Isogenic Cancer Cell Line System for Targeting the State of Mismatch Repair Deficiency,” PLOS ONE, 2013, 10, e78726. PubMed

Weidmann, A. G.; Komor, A. C.; Barton, J. K. “Biological Effects of Simple Changes in Functionality on Rhodium Metalloinsertors,” Philos. Trans. R. Soc. A., 2013, 371, 20120117. PubMed

Komor, A. C.; Barton, J. K. “The Path for Metal Complexes to a DNA Target,” Chem. Commun. 2013, 49, 3617-3630. (Cover Article) PubMed

Komor, A. C.; Schneider, C. J.; Weidmann, A. G.; Barton, J. K. “Cell-Selective Activity of Rhodium Metalloinsertors Correlates with Subcellular Localization,” J. Am. Chem. Soc. 2012, 134, 19223-19233. PubMed

Ernst, R. J.; Komor, A. C.; Barton, J. K. “Selective Cytotoxicity of Rhodium Metalloinsertors in Mismatch Repair-Deficient Cells,” Biochemistry 2011, 50, 10919-10928. PubMed

Soo, H. S.; Komor, A. C.; Iavarone, A. T.; Chang, C. J. “A Hydrogen-Bond Facilitated Cycle for Oxygen Reduction by an Acid- and Base-Compatible Iron Platform,” Inorg. Chem. 2009, 48, 10024-10035. PubMed